This morning at 0723 hrs stations 49, 48 and AMB144 were dispatched to the 1500 block of Horseshoe Pike (route 322) in West Brandywine Twp for the auto accident with injuries. AST49 arrived on scene with a box truck and a vehicle involved, with heavy damage to the vehicle and the operator still inside. Crews arrived and stabilized the vehicle then assisted EMS with packaging and removing the patient from the vehicle. AMB144 transported 1 patient to Paoli Memorial Trauma Center. Route 322 was closed from Swinehart Rd to Culbertson Run Rd during the incident and while the tow company cleared the vehicle. Fire units cleared at 0801 hrs.